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2018年度浙江省科學技術獎揭曉,我院三個項目獲獎!
作者:佚名    文章來源:本站原創    點擊數:    更新時間:2019/5/28

5月14日,2018年度浙江省科學技術獎勵大會在浙江省人民大會堂舉行。經初評、行業評審、綜合評審和兩次公示,共產生省科學技術獎項目299項。我院今年收獲頗豐,以第一單位獲二等獎1項,三等獎2項。

規范臨床研究,提供高質量循證證據

方劍喬教授團隊主持的“中西醫結合綜合康復治療缺血性腦卒中的多中心臨床研究和方案推廣”獲省科學技術二等獎。項目針對缺血性腦卒中患者,在省內六家三甲醫院開展大樣本多中心隨機對照研究,研究證實針灸結合康復治療可以改善腦卒中患者神經功能缺損程度、下肢運動功能、吞咽功能以及認知狀況等。課題組制定了“中西醫結合整體康復治療缺血性腦卒中的診療方案”通過了浙江省康復醫學會組織的專家論證,在省內 10 家醫院進行推廣應用,舉辦大型培訓講座 7 次,培訓人次超過 2800 人,應用住院患者 3000 余例,在很大程度上減輕了家庭和社會的經濟負擔。

重視基礎研究,精確闡釋中醫藥治療機制

高祥福教授團隊主持的“清固法調控TLR4/MyD88通路防治狼瘡合并妊娠丟失的機理”獲省科學技術三等獎。項目通過建立抗磷脂抗體綜合征(APS)受孕小鼠模型,研究清固方對APS受孕小鼠妊娠丟失的影響及對分別轉染MyD88和TLR4/TIR的早期滋養層細胞的干預作用以探討清熱祛瘀固腎法對抗磷脂抗體陽性妊娠的保護作用,證實清固方可通過影響TLR4/ MyD88通路而干預抗β2GPI抗體誘導的HTR8分泌炎性細胞因子(IL-8、MCP-1、IL-1β)及細胞凋亡。這一實驗結果使得我們可以用量化的現代生物學指標來闡明清熱祛瘀固腎法治療狼瘡妊娠的藥效和作用機制,為清熱祛瘀固腎方治療狼瘡妊娠提供可信的實驗依據和奠定科學的理論基礎,精準闡釋了中醫藥的治療機制。

研究《靈樞》眩暈三十年,創椎系眩暈病特色療法

范炳華教授團隊主持的“眩暈病推拿干預機制創新研究與應用”獲省科學技術三等獎。項目以《黃帝內經》“上虛則眩”理論為切入點,以椎基底動脈CT血管造影聯合灌注成像技術,研究眩暈病血管病理變化與眩暈的相關性。根據椎基底動脈血管病理變化構建三部推拿法技術,以多中心臨床評價和動物實驗研究論證推拿干預作用,形成眩暈病病理新機制,探索推拿干預的有效性。項目累計治療病人8萬余例,創新的“三部推拿法”已經成為椎系眩暈病的首選治療方法,造福廣大眩暈病患者。

(科教科/供稿

 

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